Scandal in medieval Leipzig at the beginning of the 16th century: Although cursed, the hangman's daughter Priska marries the town doctor Adam. She should actually be happy, but she knows full well that Adam will never love her. Priska takes refuge in her work as her husband's assistant, and her reputation as a miracle healer soon precedes her. She is particularly popular with the women. She helps them to prevent unwanted pregnancies. But she does not only win friends with this. Her twin sister Regina in particular envies Priska's life at Adam's side ...